منابع مشابه
Antiretroviral Drug Interactions and Adverse Side Effects
The complexity of antiretroviral therapy, coupled with the lifelong duration of treatment, presents the need for extensive management of drug interactions and adverse effects. This article includes an extensive discussion of drug interactions involving antiretroviral agents and other medications (eg, antibiotics, oral contraceptives, H2 antagonists, and lipid-lowering agents) commonly used in i...
متن کاملThe relationship between rational drug design and drug side effects
Previous analysis of systems pharmacology has revealed a tendency of rational drug design in the pharmaceutical industry. The targets of new drugs tend to be close with the corresponding disease genes in the biological networks. However, it remains unclear whether the rational drug design introduces disadvantages, i.e. side effects. Therefore, it is important to dissect the relationship between...
متن کاملPharmacogenomics--drug disposition, drug targets, and side effects.
From St. Jude Children’s Research Hospital and the University of Tennessee Colleges of Pharmacy and Medicine, Memphis (W.E.E.); and Washington University Medical School, St. Louis (H.L.M.). Address reprint requests to Dr. Evans at St. Jude Children’s Research Hospital, 332 N. Lauderdale St., Memphis, TN 381010318, or at [email protected]. t is well recognized that different patients resp...
متن کاملMetabolic Network Prediction of Drug Side Effects.
Drug side effects levy a massive cost on society through drug failures, morbidity, and mortality cases every year, and their early detection is critically important. Here, we describe the array of model-based phenotype predictors (AMPP), an approach that leverages medical informatics resources and a human genome-scale metabolic model (GSMM) to predict drug side effects. AMPP is substantially pr...
متن کاملGESSE: Predicting Drug Side Effects from Drug-Target Relationships
The in silico prediction of unwanted side effects (SEs) caused by the promiscuous behavior of drugs and their targets is highly relevant to the pharmaceutical industry. Considerable effort is now being put into computational and experimental screening of several suspected off-target proteins in the hope that SEs might be identified early, before the cost associated with developing a drug candid...
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ژورنال
عنوان ژورنال: BMJ
سال: 1968
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5598.175